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TROPONIN I
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DeCS
Descriptor
English
:
Troponin I
Descriptor
Spanish
:
Troponina I
Descriptor
Portuguese
:
Troponina I
Synonyms
English
:
Troponin I1
Troponin I2
Troponin I3
Troponin-I
Tree Number:
D05.500.945.925
D05.750.078.730.825.925
D12.776.210.500.910.925
D12.776.220.525.825.925
Definition
English
:
A
TROPONIN
complex subunit that inhibits
ACTOMYOSIN
ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three
troponin I
subtypes:
troponin
I1, I2 and I3.
Troponin
I3 is cardiac-specific whereas
troponin
I1 and I2 are skeletal subtypes.
Troponin
I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and
mutations
in
troponin
I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Indexing Annotation
English
:
TROPONIN C
&
TROPONIN T
are also available
History Note
English
:
97; was TROPONIN I (NM) 1975-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33046
Unique Identifier:
D019210
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS